tailieunhanh - Báo cáo y học: "Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort | Retrovirology BioMed Central Research Open Access Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort Meriet Mikhail1 Bin Wang1 Philippe Lemey2 Brenda Beckthold3 Anne-Mieke Vandamme2 M John Gill3 and Nitin K Saksena 1 Address Retroviral Genetics Laboratory Center for Virus Research Westmead Millennium Institute Westmead Hospital The University of Sydney Westmead NSW 2145. Sydney Australia 2Department of Clinical and Epidemiological Virology Rega Institute Minderbroedersstraat 10 B-3000 Leuven Belgium and 3Department of Medicine University of Calgary 3330 Hospital Drive NW Calgary Albert T2N 4N1 Canada Email Meriet Mikhail - meriet_mikhail@ Bin Wang - bin_wang@ Philippe Lemey - Brenda Beckthold - Anne- Mieke Vandamme - M John Gill - Nitin K Saksena - nitin_saksena@ Corresponding author Published 29 June 2005 Received 19 May 2005 Retrovirology 2005 2 41 doi 1742-4690-2-41 Accepted 29 June 2005 This article is available from http content 2 1 41 2005 Mikhail et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The actual relationship between viral variability and HIV disease progression and or non-progression can only be extrapolated through epidemiologically-linked HIV-infected cohorts. The rarity of such cohorts accents their existence as invaluable human models for a clear understanding of molecular factors that may contribute to the various rates of HIV disease. We present here a cohort of three patients with the source termed donor A - a non-progressor and .