tailieunhanh - Báo cáo y học: " Transactivation of elements in the human endogenous retrovirus W family by viral infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Transactivation of elements in the human endogenous retrovirus W family by viral infection. | Retrovirology BioMed Central Research Open Access Transactivation of elements in the human endogenous retrovirus W family by viral infection Christoffer Nellâker 1 Yuanrong Yao1 Lorraine Jones-Brando2 Francois Mallet3 Robert H Yolken2 and Hâkan Karlsson1 Address 1Frhe Department of Neuroscience Karolinska Institutet Retzius vag 8 171 77 Stockholm Sweden 2The Stanley Division of Developmental Neurovirology The Johns Hopkins University School of Medicine 600 N Wolfe Street Blalock 1105 Baltimore MD 21287-4933 USA and 3UMR 2714 CNRS-bioMérieux IFR128 BioSciences Lyon-Gerland Ecole Normale Supérieure de Lyon 46 allée d Italie 69364 Lyon cedex 07 France Email Christoffer Nellâker - Yuanrong Yao - Lorraine Jones-Brando - lbrando@ Francois Mallet - Robert H Yolken - Rhyolken@ Hâkan Karlsson - Corresponding author Published 06 July 2006 Received 31 March 2006 Retrovirology 2006 3 44 doi 1742-4690-3-44 Accepted 06 July 2006 This article is available from http content 3 1 44 2006 Nellảker et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Aberrant expression of human endogenous retrovirus HERV elements in the W family has previously been associated with schizophrenia multiple sclerosis and preeclampsia. Little is know regarding the basal expression transcriptional regulation and functional significance of individual HERV-elements. Since viral infections have previously been reported to transactivate retroviral long terminal repeat regions we examined the basal expression of HERV-W elements and following infections by influenza A WSN 33 and Herpes simplex 1 viruses in .