tailieunhanh - Báo cáo y học: " APOBEC3G targets human T-cell leukemia virus type 1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " APOBEC3G targets human T-cell leukemia virus type 1. | Retrovirology BioMed Central Research APOBEC3G targets human T-cell leukemia virus type 1 Amane Sasada1 Akifumi Takaori-Kondo 1 Kotaro Shirakawa1 Masayuki Kobayashi1 Aierkin Abudu1 Masakatsu Hishizawa1 Kazunori Imada1 Yuetsu Tanaka2 and Takashi Uchiyama1 Open Access Address Department of Hematology and Oncology Graduate School of Medicine Kyoto University 54 Shogoin-Kawaracho Sakyo-ku Kyoto 606-8507 Japan and 2Department of Immunology Graduate School and Faculty of Medicine University of the Ryukyus Uehara 207 Nishihara-cho Nakagami-gun Okinawa 903-0215 Japan Email Amane Sasada - amasasa@ AkifumiTakaori-Kondo - atakaori@ Kotaro Shirakawa - kotash@ Masayuki Kobayashi - sailing@ Aierkin Abudu - abdiriyimarkin@ Masakatsu Hishizawa - hishiza@ Kazunori Imada - imadak@ Yuetsu Tanaka - yuetsu@ Takashi Uchiyama - uchiyata@ Corresponding author Published 19 May 2005 Received 21 April 2005 Retrovirology 2005 2 32 doi 1742-4690-2-32 Accepted 19 May 2005 This article is available from http content 2 1 32 2005 Sasada et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G APOBEC3G is a host cellular protein with a broad antiviral activity. It inhibits infectivitiy of a wide variety of retroviruses by deaminating deoxycytidine dC into deoxyuridine dU in newly synthesized minus strand DNA resulting in G-to-A hypermutation of the viral plus strand DNA. To clarify the mechanism of its function we have examined the antiviral activity of APOBEC3G on human T-cell leukemia virus type

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