tailieunhanh - Báo cáo y học: " Discovery of adult T-cell leukemia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Discovery of adult T-cell leukemia. | Retrovirology BioMed Central Review Discovery of adult T-cell leukemia Kiyoshi Takatsuki Open Access Address Department of Internal Medicine II Kumamoto University School of Medicine 1-1-1 Honjo Kumamoto 860-8556 Japan Email Kiyoshi Takatsuki -tkiyo@ Corresponding author Published 02 March 2005 Received 31 January 2005 Accepted 02 March 2005 Retrovirology 2005 2 16 doi 1742-4690-2-16 H This article is available from http content 2 1 16 2005 Takatsuki licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Adult T-cell leukemia ATL was first reported as a distinct clinical entity in 1977 in Japan. The predominant physical findings are skin lesions lymphadenopathy and hepatosplenomegaly. The ATL cells are of mature T-helper phenotype and have a characteristic appearance with indented nuclei. There is striking frequent hypercalcemia with increased numbers of osteoclasts. Central to the identification of the disease is a striking geographic clustering in southwestern Japan and the isolation of human T-cell lymphotropic virus type-1 HTLV-1 from the cell lines of patients. Worldwide epidemiological studies have been made through international collaborations. Several diseases were found to be related to HTLV-1 infection. Moreover it was noted that an immunodeficiency state may be induced by HTLV-1 infection. In Japan HTLV-1 carriers have been estimated to be million and more than 700 cases of ATL have been diagnosed each year. Adult T-cell leukemia ATL was described as a distinct clinical entity in 1977 in Kyoto Japan 1 2 . The illness is manifested by presentation in adult life frequent skin lesions lymphadenopathy hepatosplenomegaly and elevated white blood cell count with .

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