tailieunhanh - Báo cáo y học: " Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe). | Retrovirology BioMed Central Open Access Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast Schizosaccharomyces pombe Zsigmond Benko1 Dong Liang1 2 Emmanuel Agbottah4 Jason Hou1 Lorena Taricani13 Paul G Young3 Michael Bukrinsky4 and Richard Y Zhao 1 2 Address Children s Memorial Research Center Departments of Pediatrics Microbiology-Immunology Feinberg School of Medicine Northwestern University Chicago Illinois USA - Departments of Pathology Microbiology-Immunology Institute of Human Virology University of Maryland School of Medicine Baltimore Maryland USA 3Department of Biology Queen s University Kingston Ontario Canada and 4Department of Microbiology and Tropical Medicine George Washington University Washington DC USA Email Zsigmond Benko - benkozigi@ Dong Liang - dliang@ Emmanuel Agbottah - etagbottah@ Jason Hou - jkh772@ Lorena Taricani - ltaricani@ Paul G Young - youngpg@ Michael Bukrinsky - mtmmib@ Richard Y Zhao - rzhao@ Corresponding author fEqual contributors Published 7 March 2007 Received 5 January 2007 Accepted 7 March 2007 Retrovirology 2007 4 16 doi l 742-4690-4-16 This article is available from http content 4 1 16 2007 Benko et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Expression of the HIV-1 vpr gene in human and fission yeast cells displays multiple highly conserved activities which include induction of cell cycle G2 arrest and cell death. We have previously characterized a yeast heat shock protein 16 Hsp16 that suppresses the Vpr activities when it is overproduced in fission yeast. .