tailieunhanh - Báo cáo y học: " Open Access SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Open Access SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. | BioMed Central Retrovirology Open Access SIVsm HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells Caroline Goujon1 Lise Rivière1 Loraine Jarrosson-Wuilleme1 Jeanine Bernaud2 Dominique Rigal2 Jean-Luc Darlix1 and Andrea Cimarelli 1 Address 1LaboRetro INSERM U758 Ecole Normale Supérieure de Lyon IFR 128 BioSciences Lyon-Gerland Lyon-Biopole France and 2Etablissement Fran ais du Sang Lyon France Email Caroline Goujon - cgoujon@ Lise Rivière - lriviere@ Loraine Jarrosson-Wuilleme - ljarross@ Jeanine Bernaud - Dominique Rigal - dominiquerigal@ Jean-Luc Darlix - jldarlix@ Andrea Cimarelli - acimarel@ Corresponding author Published 09 January 2007 Received 19 December 2006 Accepted 09 January 2007 Retrovirology 2007 4 2 doi l742-4690-4-2 p This article is available from http content 4 1 2 2007 Goujon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Vpx is a non-structural protein coded by members of the SIVsm HIV-2 lineage that is believed to have originated by duplication of the common vpr gene present in primate lentiviruses. Vpx is incorporated into virion particles and is thus present during the early steps of viral infection where it is thought to drive nuclear import of viral nucleoprotein complexes. We have previously shown that Vpx is required for SIVMAC-derived lentiviral vectors LVs infection of human monocyte-derived dendritic cells DCs . However since the requirement for Vpx is specific for DCs and not for other .

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