tailieunhanh - Báo cáo y học: " Formulas Competing risks models and time-dependent covariates"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Formulas Competing risks models and time-dependent covariates. | Available online http content 12 2 134 Commentary Competing risks models and time-dependent covariates Adrian Barnett and Nick Graves Institute of Health and Biomedical Innovation Queensland University of Technology 60 Musk Avenue Kelvin Grove Urban Village Kelvin Grove Queensland 4059 Australia Corresponding author Adrian Barnett Published 11 April 2008 This article is online at http content 12 2 134 2008 BioMed Central Ltd Critical Care 2008 12 134 doi cc6840 See related research by Wolkewitz et al. http content 12 2 R44 Abstract New statistical models for analysing survival data in an intensive care unit context have recently been developed. Two models that offer significant advantages over standard survival analyses are competing risks models and multistate models. Wolkewitz and colleagues used a competing risks model to examine survival times for nosocomial pneumonia and mortality. Their model was able to incorporate time-dependent covariates and so examine how risk factors that changed with time affected the chances of infection or death. We briefly explain how an alternative modelling technique using logistic regression can more fully exploit time-dependent covariates for this type of data. In the present issue of Critical Care Wolkewitz and colleagues use competing risks models to examine risk factors for nosocomial pneumonia and mortality in an intensive care unit 1 . Competing risks models offer significant advantages over standard survival analysis 2 . In a standard survival analysis there is one event for example death and one time for example days until death . Often we have a set of covariates and want to know which are most predictive of the event. In competing risks models the number of events can be greater than one. In the study by Wolkewitz and colleagues there were three competing risks nosocomial pneumonia death and discharge. Covariates can depend on the competing risk. A good .

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