tailieunhanh - Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells

Many tumor types exhibit an impaired Pasteur effect, . despite the pres-ence of oxygen, glucose is consumed at an extraordinarily high rate com-pared with the tissue from which they originate – the so-called ‘Warburg effect’. | ẶFEBS Journal REVIEW ARTICLE Enzymatic features of the glucose metabolism in tumor cells Anique Herling Matthias Konig Sascha Bulik and Hermann-Georg Holzhutter University Medicine Berlin Charite Institute of Biochemistry ComputationalBiochemistry Group Germany Keywords aerobic cancer enzyme glucose glycolysis isozymes metabolism TCA cycle tumor Warburg effect Correspondence . Holzhutter University Medicine Berlin Charite Institute of Biochemistry Computational Biochemistry Group Reinickendorfer Strasse 61 13149 Berlin Germany Fax 49 30 450 528 937 Tel 49 30 450 528 166 E-mail hergo@ Received 4 February 2011 revised 4 April 2011 accepted 9 May 2011 doi Many tumor types exhibit an impaired Pasteur effect . despite the presence of oxygen glucose is consumed at an extraordinarily high rate compared with the tissue from which they originate - the so-called Warburg effect . Glucose has to serve as the source for a diverse array of cellular functions including energy production synthesis of nucleotides and lipids membrane synthesis and generation of redox equivalents for antioxidative defense. Tumor cells acquire specific enzyme-regulatory mechanisms to direct the main flux of glucose carbons to those pathways most urgently required under challenging external conditions such as varying substrate availability presence of anti-cancer drugs or different phases of the cell cycle. In this review we summarize the currently available information on tumor-specific expression activity and kinetic properties of enzymes involved in the main pathways of glucose metabolism with due regard to the explanation of the regulatory basis and physiological significance of the Warburg effect. We conclude that besides the expression level of the metabolic enzymes involved in the glucose metabolism of tumor cells the unique tumor-specific pattern of isozymes and accompanying changes in the metabolic regulation below the translation level enable