tailieunhanh - Báo cáo y học: "Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats. | Available online http content 1 2 2 R39 Research Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats Virginia Chamorro-Marin1 3 Manuel Garcia-Delgado2 3 Angel Touma-Fernandez2 3 Eduardo Aguilar-Alonso2 3 and Enrique Fernandez-Mondejar2 3 1Unidad Experimental Hospital Universitario Virgen de las Nieves C Dr. Azpitarte n 4 18014 Granada Spain 2Servicio de Cuidados Criticos y Urgencias Hospital Universitario Virgen de las Nieves Avda. Fuerzas Armadas n 2 18014 Granada Spain 3Servicio de Cuidados Criticos y Urgencias Hospital Universitario Virgen de las Nieves Avda. Fuerzas Armadas n 2 18014 Granada Spain Corresponding author Virginia Chamorro-Marin vchamo26@ Received 28 Jun 2007 Revisions requested 7 Aug 2007 Revisions received 14 Nov 2007 Accepted 10 Mar 2008 Published 10 Mar 2008 Critical Care 2008 12 R39 doi cc6829 This article is online at http content 12 2 R39 2008 Chamorro-Marin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Intoduction Clearance of alveolar oedema depends on active transport of sodium across the alveolar-epithelial barrier. p-Adrenergic agonists increase clearance of pulmonary oedema but it has not been established whether p-agonist stimulation achieves sufficient oedema clearance to improve survival in animals. The objective of this study was to determine whether the increased pulmonary oedema clearance produced by intratracheal dopamine improves the survival of rats after mechanical ventilation with high tidal volume HVT . Methods This was a randomized controlled experimental study. One hundred and thirty-two Wistar-Kyoto rats weighing 250 to 300 g were anaesthetized