tailieunhanh - Báo cáo y học: "Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage. | Available online http content 1 2 1 R9 Research Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage Florian Schlenk1 Daniela Graetz1 Alexandra Nagel1 Maren Schmidt2 and Asita S Sarrafzadeh1 Department of Neurosurgery Charité Campus Virchow Medical Center Augustenburger Platz 13353 Berlin Germany department of Anaesthesiology and Intensive Care Medicine Charité Campus Virchow Medical Center Augustenburger Platz 13353 Berlin Germany Corresponding author Asita S Sarrafzadeh Received 21 Aug 2007 Revisions requested 5 Oct 2007 Revisions received 1 Dec 2007 Accepted 24 Jan 2008 Published 24 Jan 2008 Critical Care 2008 12 R9 doi cc6776 This article is online at http content 12 1 R9 2008 Schlenk et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Introduction Hyperglycaemia following aneurysmal subarachnoid hemorrhage SAH is associated with complications and impaired neurological recovery. The aim of this study was to determine the effect of insulin treatment for glucose control on cerebral metabolism in SAH patients. Methods This prospective nonrandomized study was conducted in 31 SAH patients in an intensive care unit age 52 10 years World Federation of Neurological Surgeons grade . A microdialysis catheter was inserted into the vascular territory of the aneurysm after clipping. Blood glucose levels above 140 mg dl were treated with intravenous insulin and the microdialysates were analyzed hourly for the first 12 hours of infusion. Results No hypoglycaemia occurred. Twenty-four patients were treated with insulin for glucose control. Higher age and World Federation of Neurological Surgeons score