tailieunhanh - Báo cáo hóa học: " Surviving sepsis: going beyond the guidelines"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Surviving sepsis: going beyond the guidelines | Marik Annals of Intensive Care 2011 1 17 http content 1 1 17 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Surviving sepsis going beyond the guidelines Paul E Marik Abstract The Surviving Sepsis Campaign is a global effort to improve the care of patients with severe sepsis and septic shock. The first Surviving Sepsis Campaign Guidelines were published in 2004 with an updated version published in 2008. These guidelines have been endorsed by many professional organizations throughout the world and come regarded as the standard of care for the management of patients with severe sepsis. Unfortunately most of the recommendations of these guidelines are not evidence-based. Furthermore the major components of the 6-hour bundle are based on a single-center study whose validity has been recently under increasing scrutiny. This paper reviews the validity of the Surviving Sepsis Campaign 6-hour bundle and provides a more evidence-based approach to the initial resuscitation of patients with severe sepsis. Sepsis is among the most common reasons for admission to intensive care units ICUs throughout the world. During the past two decades the incidence of sepsis in the United States has tripled and is now the tenth leading cause of death. In the United States alone approximately 750 000 cases of sepsis occur each year at least 225 000 of which are fatal 1 2 . Septic patients are generally hospitalized for extended periods rarely leaving the ICU before 2-3 weeks. Despite the use of antimicrobial agents and advanced life-support the case fatality rate for patients with sepsis has remained between 20 and 30 during the past 2 decades 1 2 . The Surviving Sepsis Campaign SSC is a global effort to improve the care of patients with severe sepsis and septic shock. The campaign was launched by the Society of Critical Care Medicine the European Society of Intensive Care Medicine and the International Sepsis Forum in 2002. The first .