tailieunhanh - Báo cáo y học: "An anti-inflammatory role for tranexamic acid in cardiac surgery"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: An anti-inflammatory role for tranexamic acid in cardiac surgery? | Available online http content 12 1 105 Commentary An anti-inflammatory role for tranexamic acid in cardiac surgery Heidi J Robertshaw 1 2 1St George s Hospital Blackshaw Road London SW17 0QT UK 2Department of Anaesthesia Alice Springs Hospital Gap Road Alice Springs NT 0870 Australia Corresponding author Heidi J RobertshaW hroberts@ Published 16 January 2008 This article is online at http content 12 1 105 2008 BioMed Central Ltd Critical Care 2008 12 105 doi cc6210 See related research by Jimenez et al. http content 11 6 R117 Abstract Pro- and anti-inflammatory cytokines are elevated after cardiac surgery. The control of the release of these major paracrine proteins is becoming clearer and they have been shown to be involved in the activation of the coagulation fibrinolysis pathway among other cascades. The association of a predominance of pro-inflammatory cytokines with morbidity in some patients particularly following cardiac surgery is well described but still incompletely understood. Clinical studies elucidating how clinicians may influence this cytokine release directly will improve our knowledge of the processes involved and could ultimately show benefit in better outcomes for patients. Cytokines are an intriguing group of soluble protein mediators with a large number of described actions but short biological range. These molecules are produced by a variety of cells including monocytes macrophages lymphocytes and endothelial cells. Such proteins include the pro-inflammatory cytokines interleukin IL -6 and soluble tumour necrosis factor receptor-1 sTNFR-1 as measured by Jimenez and colleagues 1 in their study. Cytokines have been shown to be important in all biological processes 2 including inflammation in which the major pro-inflammatory cytokines are considered to be tumour necrosis factor TNF IL-1 and interferon-gamma in addition to IL-6. They also have anti-inflammatory roles IL-10 transforming growth