tailieunhanh - Báo cáo y học: " Ventilator-induced lung injury and mechanotransduction: why should we care"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Ventilator-induced lung injury and mechanotransduction: why should we care? | Available online http content 11 5 168 Commentary Ventilator-induced lung injury and mechanotransduction why should we care Mingyao Liu 1 1 Department of Surgery Faculty of Medicine University of Toronto Toronto Ontario Canada Corresponding author Mingyao Liu Published 26 October 2007 This article is online at http content 11 5 168 2007 BioMed Central Ltd Critical Care 2007 11 168 doi cc6131 See related research by Li et al http content 11 5 R89 Abstract Mechanotransduction holds the underlying mechanisms of ventilator-induced lung injury. Research on this subject however could be difficult for clinicians especially when results are controversial. A recent study by Li and co-workers is used as an example to explain how to critically read literatures related to basic science and how to understand the limitation of experimental studies. As a professor in a clinical department I am privileged to work with many clinician-investigator trainees. Recently a new clinical research fellow told me that he had been reading many papers in order to decide which research project he should take. The more he reads the more confused he feels. Many literatures sound contradictory. How to determine their clinical relevance is a challenge. In fact this challenge is not only to new fellows but also to experienced researchers. In this issue of Critical Care Dr Li and Dr Quinn and their colleagues published a research article 1 exploring the molecular mechanisms of ventilator-induced lung injury VILI . I would like to use this interesting article as an example to lead readers who are not experts in this field through a translational process. Mechanical force-induced signal transduction mechanotransduction is responsible for many physiological processes in lung development 2 in maintaining lung functions 3 and in pathological conditions related to lung diseases such as asthma chronic obstructive pulmonary disease COPD and