tailieunhanh - Báo cáo y học: "Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung. | Available online http content 11 5 R104 Research Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung Lucio Pavone1 Scott Albert1 Joseph DiRocco1 Louis Gatto2 and Gary Nieman1 Open Access 1Upstate Medical University Department of Surgery 750 E Adams Street Syracuse NY 13210 USA 2Department of Biology Cortland College . Box 2000 Cortland NY 13045 USA Corresponding author Scott Albert albertsc@ Received 26 Jun 2007 Revisions requested 27 Jul 2007 Revisions received 6 Sep 2007 Accepted 18 Sep 2007 Published 18 Sep 2007 Critical Care 2007 11 R104 doi cc6122 This article is online at http content 11 5 R1 04 2007 Pavone et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Septic shock is often associated with acute respiratory distress syndrome a serious clinical problem exacerbated by improper mechanical ventilation. Ventilator-induced lung injury VILI can exacerbate the lung injury caused by acute respiratory distress syndrome significantly increasing the morbidity and mortality. In this study we asked the following questions what is the effect of the lung position dependent lung versus nondependent lung on the rate at which VILI occurs in the normal lung Will positive end-expiratory pressure PEEP slow the progression of lung injury in either the dependent lung or the nondependent lung Materials and methods Sprague-Dawley rats n 19 were placed on mechanical ventilation and the subpleural alveolar mechanics were measured with an in vivo microscope. Animals were placed in the lateral decubitus position left lung up to measure nondependent alveolar mechanics and left lung down to film dependent alveolar mechanics. .