tailieunhanh - Báo cáo y học: "Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance. | Available online http content 11 6 R118 Research Variation in the PaO2 FiO2 ratio with FiO2 mathematical and experimental description and clinical relevance Dan S Karbing1 Soren Kj rgaard2 Bram W Smith1 Kurt Espersen3 Charlotte Allerod1 2 Steen Andreassen1 and Stephen E Rees1 Center for Model-based Medical Decision Support Department of Health Science and Technology Aalborg University Fredrik Bajers Vej 7 E4-215 DK-9220 Aalborg East Denmark 2Anaesthesia and Intensive Care Region North Jutland Aalborg Hospital Aarhus University DK-9000 Aalborg Denmark 3Department of Intensive Care Rigshospitalet University of Copenhagen DK-2100 Copenhagen East Denmark Corresponding author Dan S Karbing dank@ Received 2 Aug 2007 Revisions requested 8 Sep 2007 Revisions received 2 Oct 2007 Accepted 7 Nov 2007 Published 7 Nov 2007 Critical Care 2007 11 R118 doi cc6174 This article is online at http content 11 6 R118 2007 Karbing et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Previous studies have shown through theoretical analyses that the ratio of the partial pressure of oxygen in arterial blood PaO2 to the inspired oxygen fraction FiO2 varies with the FiO2 level. The aim of the present study was to evaluate the relevance of this variation both theoretically and experimentally using mathematical model simulations comparing these ratio simulations with PaO2 FiO2 ratios measured in a range of different patients. Methods The study was designed as a retrospective study using data from 36 mechanically ventilated patients and 57 spontaneously breathing patients studied on one or more occasions. Patients were classified into four disease groups normal mild hypoxemia .

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