tailieunhanh - Báo cáo y học: "Clinical review: Major consequences of illicit drug consumption"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: Major consequences of illicit drug consumption. | Available online http content 12 1 202 Review Clinical review Major consequences of illicit drug consumption Robert J Devlin1 and John A Henry2 1Guy s and St Thomas NHS Foundation Trust Lambeth Palace Road London SE1 7EH UK 2Department of Emergency Medicine St Mary s Hospital South Wharf Road London W2 1NY UK Corresponding author John A Henry Published 11 January 2008 This article is online at http content 12 1 202 2008 BioMed Central Ltd Critical Care 2008 12 202 doi cc6166 Abstract Because illicit drugs are now widely consumed every doctor needs to know their acute medical consequences and complications. Here we review the problems associated with the different drugs from a systems-based viewpoint. Apart from the respiratory depressant effect of opioids crack cocaine is the most common cause of respiratory complications mainly linked with its mode of use with airway burns pneumothorax pneumomediastinum and lung syndromes being well-recognised sequelae. Because of its marked cardiovascular effects cocaine is also a major cause of coronary syndromes and myocardial infarction. Amphetamines may produce similar effects less commonly. Hyperthermia may occur with cocaine toxicity or with 3 4-methylenedioxymethamphetamine MDMA due to exertion or from serotonin syndrome. Cerebral haemorrhage may result from the use of amphetamines or cocaine. Hallucinations may follow consumption of LSD amphetamines or cocaine. MDMA is a major cause of acute severe hyponatraemia and also has been linked with hepatic syndromes. Collapse convulsions or coma may be caused in different circumstances by opioids MDMA or gamma hydroxybutyrate and may be aggravated by other sedatives especially alcohol and benzodiazepines. Recognition of these acute complications is urgent and treatment must be based on an understanding of the likely underlying problem as well as on basic principles of supportive care. Introduction Many substances are now .