tailieunhanh - Báo cáo y học: "An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation. | Available online http content 11 5 R111 Research An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation Maria MJ van der Vorst1 2 Jan den Hartigh3 Enno Wildschut4 Dick Tibboel2 and Jacobus Burggraaf1 Centre for Human Drug Research Leiden The Netherlands 2Department of Paediatric Surgery Erasmus Medical Centre Rotterdam The Netherlands department of Clinical Pharmacy and Toxicology Leiden University Medical Center Leiden The Netherlands 4Department of Paediatrics Erasmus Medical Centre Rotterdam The Netherlands Corresponding author DickTibboel Received 12 Apr 2007 Revisions requested 13 Jun 2007 Revisions received 24 Jul 2007 Accepted 10 Oct 2007 Published 10 Oct 2007 Critical Care 2007 11 R111 doi cc6146 This article is online at http content 11 5 R111 2007 van der Vorst et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective of the present study was to explore a continuous intravenous furosemide regimen that adapts to urine output in neonates treated with extracorporeal membrane oxygenation ECMO . Methods Seven neonates admitted to a paediatric surgical intensive care unit for ECMO therapy were treated with a furosemide regimen consisting of a loading bolus 1-2 mg kg followed by a continuous infusion at mg kg per hour which was adjusted according to the target urine production of 6 ml kg per hour. Therapeutic drug monitoring for furosemide concentrations in blood was performed. Results The mean standard deviation furosemide dose was mg kg per hour mg kg per hour and mg kg per hour respectively on the first