tailieunhanh - Báo cáo y học: "Phosphodiesterase 3 inhibition and cough in elderly asthmatics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Phosphodiesterase 3 inhibition and cough in elderly asthmatics. | Cough BioMed Central Research Open Access Phosphodiesterase 3 inhibition and cough in elderly asthmatics Yoshihisa Ishiura 1 Masaki Fujimura2 Kouichi Nobata2 Miki Abo1 Takayoshi Oribe1 Shigeharu Myou2 and Hiroyuki Nakamura1 Address The Department of Internal Medicine Toyama City Hospital Toyama Japan and 2Respiratory Medicine Cellular Transplantation Biology Kanazawa University Graduate School of Medicine Kanazawa Japan Email Yoshihisa Ishiura - ishiura@ Masaki Fujimura - fujimura@ Kouichi Nobata - nobata@ Miki Abo - abo@ Takayoshi Oribe - orib@ Shigeharu Myou - myou@ Hiroyuki Nakamura - nakamura-h@ Corresponding author Published 24 November 2005 Received 05 June 2005 Cough 2005 1 11 doi 1745-9974-1-11 Accepted 24 November 2005 This article is available from http content 1 1 1 1 2005 Ishiura et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Aims Cough is a common symptom of bronchial asthma a chronic inflammatory airway disease. Recently the therapeutic effects of selective phosphodiesterase PDE inhibitors have been focused on bronchial asthma. This study was designed to investigate the clinical effect of PDE 3 inhibition on cough reflex sensitivity in elderly patients with bronchial asthma. Methods Effects of cilostazol a PDE 3 inhibitor on cough response to inhaled capsaicin were examined in 1 1 patients over 70 years with stable asthma in a randomized placebo-controlled cross over study. Capsaicin cough threshold defined as the lowest concentration of capsaicin eliciting five or more coughs was measured as an index of airway .

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