tailieunhanh - Báo cáo y học: "Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment. | Available online http content 11 4 R89 Research Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration a prospective controlled animal experiment Li-Fu Li1-2 Shuen-Kuei Liao3 Cheng-Huei Lee1 2 Chung-Chi Huang1 2 and Deborah A Quinn4 5 Division of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital and Chang Gung University Kweishan Taoyuan 333 Taiwan 2Department of Respiratory Therapy Chang Gung Memorial Hospital Kweishan Taoyuan 333 Taiwan 3Graduate Institute of Clinical Medical Sciences Chang Gung University Kweishan Taoyuan 333 Taiwan 4Pulmonary and Critical Care Units Department of Medicine Massachusetts General Hospital and Harvard Medical School Massachusetts USA 5Novartis Institute of Biomedical Research Cambridge Massachusetts USA Corresponding author Deborah A Quinn dquinn1 @ Received 12 Jun 2007 Revisions requested 11 Jul 2007 Revisions received 16 Jul 2007 Accepted 23 Aug 2007 Published 23 Aug 2007 Critical Care 2007 11 R89 doi cc61 01 This article is online at http content 11 4 R89 2007 Li et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Positive pressure ventilation with large tidal volumes has been shown to cause release of cytokines including macrophage inflammatory protein-2 MIP-2 a functional equivalent of human IL-8 and neutrophil infiltration. Hyperoxia has been shown to increase ventilator-induced lung injury but the mechanisms regulating interaction between a large tidal volume and hyperoxia are unclear. We hypothesized that large tidal volume ventilation using hyperoxia would increase MIP-2 production and neutrophil infiltration via the serine threonine .

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