tailieunhanh - Báo cáo y học: "Glimepiride-induced cholestasis in a man with diabetes mellitus: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Glimepiride-induced cholestasis in a man with diabetes mellitus: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Glimepiride-induced cholestasis in a man with diabetes mellitus a case report 2 3 Hesham Omar 1 Jaya Kolla Devanand Mangar and Enrico Camporesi Addresses department of Cardiovascular Medicine Cairo University Hospital Cairo Egypt 2Tampa General Hospital Tampa FL USA 3Florida Gulf to Bay Anesthesiology Tampa FL USA 4University of South Florida Tampa FL USA Email HO - hesham_engy2008@ JK - jaykolla@ DM - dmangar@ EC - ecampore@ Corresponding author Received 13 October 2008 Accepted 6 March 2009 Published 15 September 2009 Journal of Medical Case Reports 2009 3 9257 doi 1752-1947-3-9257 This article is available from http jmedicalcasereports article view 9257 2009 Omar et al. licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction There has been a progressive increase in the incidence of type II diabetes mellitus cases over the past decade. The availability of a wide variety of oral hypoglycemics has given rise to a number of adverse effects. In this case report we describe the case of a patient recently diagnosed with type II diabetes. He was receiving treatment with glimepiride and experienced rapid onset of cholestatic liver injury as a side effect which reversed upon cessation of therapy. Case presentation We present the case of a 58-year-old Egyptian man with a recent diagnosis of type II diabetes mellitus. He presented with a clinical picture of progressive jaundice three days before admission. Laboratory investigations revealed elevated bilirubin alkaline phosphatase and gamma glutamyl transferase levels. Ultrasonography revealed intrahepatic biliary duct dilatation and .