tailieunhanh - Báo cáo y học: "Factor VII and the brain: time to get this research done"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Factor VII and the brain: time to get this research done! | Available online http content 11 4 161 Commentary Factor VII and the brain time to get this research done Richard P Dutton University of Maryland School of Medicine R Adams Cowley Shock Trauma Center University of Maryland Medical System MA USA Corresponding author Richard P Dutton rdutton@ Published 31 August 2007 This article is online at http content 11 4 161 2007 BioMed Central Ltd Critical Care 2007 11 161 doi cc6097 See related research by Kluger et al. http content 11 4 R85 Abstract Traumatic brain injury is the leading killer after trauma in part because of coagulopathy. Factor Vila may be a useful therapy in this setting depending on the relative risk for thromboembolic complications. Kluger and coworkers recently conducted a retrospective review of patients with traumatic brain injury from a previous factor Viia and trauma trial. it documents an encouragingly low rate of complications and should provide a strong incentive to conduct a prospective study of factor Viia in patients with severe traumatic brain injury. Kluger and colleagues 1 have done us a service with their careful review of outcomes in patients with traumatic brain injury TBI from a previous factor Vila FVIIa trauma trial. Although the numbers are small this work will be important in motivating future prospective trials. Mortality in this small cohort was greater than in the overall study population emphasizing the lethality of TBI plus shock. The lack of selfreported thromboembolic events is encouraging and is in accordance with other prospective trials of FVIIa use which have suggested that the risk is real but not excessive. Also encouraging are the trends in the outcome variables reported including mortality and organ failure end-points. Although none of these are significant in themselves they are collectively significant in that they all vary in the same way favoring FVIIa. Traumatic brain injury TBI is the most common .