tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis. | Available online http content 11 5 228 Review Bench-to-bedside review Developmental influences on the mechanisms treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis Wendy A Luce1 Timothy M Hoffman2 and John Anthony Bauer1 2 1 Division of Neonatology Center for Cardiovascular Medicine Columbus Children s Research Institute Columbus Children s Hospital 700 Children s Drive Columbus OH 43205 USA 2Division of Cardiology and Cardiac Critical Care Center for Cardiovascular Medicine Columbus Children s Research Institute Columbus Children s Hospital Columbus OH 43205 USA Corresponding author Wendy A Luce lucew@ Published 24 September 2007 This article is online at http content 11 5 228 2007 BioMed Central Ltd Critical Care 2007 11 228 doi cc6091 Abstract Sepsis is a significant cause of morbidity and mortality in neonates and adults and the mortality rate doubles in patients who develop cardiovascular dysfunction and septic shock. Sepsis is especially devastating in the neonatal population as it is one of the leading causes of death for hospitalized infants. In the neonate there are multiple developmental alterations in both the response to pathogens and the response to treatment that distinguish this age group from adults. Differences in innate immunity and cytokine response may predispose neonates to the harmful effects of pro-inflammatory cytokines and oxidative stress leading to severe organ dysfunction and sequelae during infection and inflammation. Underlying differences in cardiovascular anatomy function and response to treatment may further alter the neonate s response to pathogen exposure. Unlike adults little is known about the cardiovascular response to sepsis in the neonate. In addition recent research has demonstrated that the mechanisms inflammatory response response to treatment and outcome of neonatal sepsis vary not only from that of adults but vary among neonates based on .