tailieunhanh - Báo cáo y học: "Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. | Available online http content 11 4 R84 Research Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children a prospective cohort study Michael Zappitelli1 Kimberly K Washburn1 Ayse A Arikan1 Laura Loftis1 Qing Ma2 Prasad Devarajan2 Chirag R Parikh3 and Stuart L Goldstein1 1Texas Children s Hospital Fannin Street Houston Texas 77030 USA 2Cincinnati Children s Hospital Medical Center Burnet Avenue Cincinnati Ohio 45229-3039 USA 3Yale University School of Medicine Campbell Avenue West Haven Connecticut 06516 USA Contributed equally Corresponding author Stuart L Goldstein stuartg@ Received 20 Apr 2007 Revisions requested 16 May 2007 Revisions received 23 May 2007 Accepted 2 Aug 2007 Published 2 Aug 2007 Critical Care 2007 11 R84 doi cc6089 This article is online at http content 11 4 R84 2007 Zappitelli et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Serum creatinine is a late marker of acute kidney injury AKI . Urine neutrophil gelatinase-associated lipocalin uNGAL is an early marker of AKI where the timing of kidney injury is known. It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in critically ill children. Methods This was a prospective cohort study of critically ill children. Children aged between 1 month and 21 years who were mechanically ventilated and had a bladder catheter inserted were eligible. Patients with end-stage renal disease or who had just undergone kidney transplantation were excluded. Patients were enrolled within 24 to 48 hours of initiation of mechanical .