tailieunhanh - Báo cáo y học: " Bench-to-bedside review: High-mobility group box 1 and critical illnes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: High-mobility group box 1 and critical illness. | Available online http content 11 5 229 Review Bench-to-bedside review High-mobility group box 1 and critical illness Mitchell P Fink Departments of Critical Care Medicine Surgery and Pharmacology University of Pittsburgh 3550 Terrace Street Pittsburgh PA 15261 USA Corresponding author Mitchell P Fink Published 19 September 2007 This article is online at http content 11 5 229 2007 BioMed Central Ltd Critical Care 2007 11 229 doi cc6088 Abstract High-mobility group box 1 HMGB1 is a DNA-binding protein that also exhibits proinflammatory cytokine-like activity. HMGB1 is passively released by necrotic cells and also is actively secreted by immunostimulated macrophages dendritic cells and enterocytes. Although circulating HMGB1 levels are increased relative to healthy controls in patients with infections and severe sepsis plasma or serum HMGB1 concentrations do not discriminate reliably between infected and uninfected critically ill patients. Nevertheless administration of drugs that block HMGB1 secretion or of anti-HMGB1 neutralizing antibodies has been shown to ameliorate organ dysfunction and or improve survival in numerous animal models of critical illness. Because HMGB1 tends to be released relatively late in the inflammatory response at least in animal models of endotoxemia or sepsis this protein is an attractive target for the development of new therapeutic agents for the treatment of patients with various forms of critical illness. Introduction Originally identified in the early 1960s 1 high-mobility group HMG proteins have been isolated and characterized from a wide variety of eukaryotic species ranging from yeast to humans 2 . Based on the presence of characteristic functional sequences three HMG subgroups have been identified 3-5 the HMGB family the HMGN family and the HMGA family. All HMG proteins bind DNA and are soluble in 5 perchloric acid 2 . HMG proteins all have an unusual amino acid .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.