tailieunhanh - Báo cáo y học: " Ileocaecal recurrence of Merkel cell carcinoma of the skin: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Ileocaecal recurrence of Merkel cell carcinoma of the skin: a case report | Cheung et al. Journal of Medical Case Reports 2010 4 43 http content 4 1 43 JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Ileocaecal recurrence of Merkel cell carcinoma of the skin a case report Michelle Cheung Henry Lee Sanjay Purkayastha Robert Goldin Paul Ziprin Abstract Introduction Merkel cell carcinoma is an uncommon skin malignancy that has a high propensity for metastatic spread. A systematic literature search identified 17 cases describing metastasis to the gastrointestinal tract with 7 cases involving the small or large bowel. To the best of our knowledge this is the only case described of Merkel cell carcinoma metastasising to the ileocaecal valve. Case presentation We present a 74-year-old Filipino woman diagnosed with Merkel cell carcinoma of the skin with regional node involvement. Following excision and radiotherapy the tumour recurred with metastasis to the ileocaecal valve. The patient died 28 months after the initial diagnosis. Conclusion The prognosis of metastatic Merkel cell carcinoma is poor. Currently the optimal management for metastatic disease is unclear and lacks a firm evidence base due to the small number of cases reported. Introduction Merkel cell carcinoma MCC is an uncommon and highly aggressive skin malignancy. It arises from Merkel cells at the dermo-epidermal junction which are of neuroendocrine origin. Since its first description by Toker in 1972 1 more than 2000 cases have been reported in the literature 2 . Its aetiology is not entirely known but there is convincing evidence for the role of ultraviolet radiation. MCC has a predilection for sun-exposed areas of the body and is associated with other sun-related skin cancers such as basal cell carcinoma and squamous cell carcinoma. The occurrence of MCC in areas that are not exposed to the sun suggests additional causes. Reports of MCC in organ transplant human immunodeficiency virus HIV infection and lymphohemopoietic malignancies such as