tailieunhanh - Báo cáo hóa học: " FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study | Zhang et al. Annals of Intensive Care 2011 1 21 http content 1 1 21 Ù Annals of Intensive Care a SpringerOpen Journal RESEARCH Open Access FGF-23 and PTH levels in patients with acute kidney injury A cross-sectional case series study 7 vs z i 1 D - k I I_I r I I2 h I n I V S I_I r i 12 IX r 1 r 1 1 í IX V kr h3 G r 1 z i l I I r I z 3 A I I 74 I h ỉ r ỉ I k I v x4 iviaryAnn Zhang Raymond Hsu Chi-yuan Hsu Kristina Kordesch trica Nicasio Alfredo Cortez Ian McAlpine o V X I 3 I_I X I I z t 7 hl I z 3 IXI rr ri r l I X- k- 1 - i7-J- i ir 5 K G - o I k- 4 vr l c f I f k k6 k I LX S h I CX V h I III2 Sandra Brady nanjing Zhuo Kirsten N Kangeiaris John Stein Carolyn S caifee ana Kathleen D Liu Abstract Background Fibroblast growth factor-23 FGF-23 a novel regulator of mineral metabolism is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone PTH levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury with a median FGF-23 level of 1948 RU mL interquartile range IQR 437-4369 in cases compared with 252 RU mL IQR 65-533 in controls p . No correlations were observed between FGF-23 and severity of acute kidney injury defined by the Acute Kidney Injury Network criteria among patients with acute kidney injury FGF-23 levels were higher in nonsurvivors than survivors median levels of 4446 RU mL IQR 34555443 versus 544 RU mL IQR 390-1948 p . Severe hyperparathyroidism defined as intact PTH 250 mg dL was present in 3 of 12 25 .

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