tailieunhanh - Báo cáo hóa học: " Synthesis and characterisation of biologically compatible TiO2 nanoparticles"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Synthesis and characterisation of biologically compatible TiO2 nanoparticles | Cheyne et al. Nanoscale Research Letters 2011 6 423 http content 6 1 423 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Synthesis and characterisation of biologically compatible TiO2 nanoparticles Richard W Cheyne1 2 Tim AD Smith2 Laurent Trembleau 1 and Abbie C Mclaughlin1 Abstract We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from presynthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance. Introduction Organically functionalised inorganic nanoparticles are being increasingly studied as a result of their many technological applications. In particular the synthesis of inorganic nanoparticles for biomedical applications is being widely researched. Biomedical applications of inorganic nanoparticles include biosensing 1 targeted drug delivery agents 2 and contrast agents in magnetic resonance imaging MRI 3 4 . Surface-coated superparamagnetic iron oxide nanoparticles have been extensively employed as magnetic resonance signal enhancers that can resolve the weakness of current MRI techniques. Most recently it has been shown that by conjugating surface-coated Au-Fe3O4 nanoparticles to both herceptin and cis-platin the nanoparticles can act as target-specific nanocarriers to deliver platin into Her2-positive breast cancer cells with strong therapeutic results 5 . Furthermore these nanoparticles can act as both a magnetic and optical probe for tracking the