tailieunhanh - Báo cáo y học: "Clozapine-induced interstitial nephritis – a rare but important complication: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Clozapine-induced interstitial nephritis – a rare but important complication: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Clozapine-induced interstitial nephritis - a rare but important complication a case report Robert Hunter1 2 Tracey Gaughan1 Filippo Queirazza1 Dina McMillan1 and Susan Shankie1 Addresses 1Gartnavel Royal Hospital Glasgow G12 0XH Scotland UK 2Psychiatric Research Institute for Neuroscience in Glasgow West Medical Building University of Glasgow Glasgow G12 8QQ Scotland UK Email RH - Corresponding author Received 15 May 2008 Accepted 9 February 2009 Published 27 August 2009 Journal ofMedical Case Reports 2009 3 8574 doi 1752-1947-3-8574 This article is available from http jmedicalcasereports article view 8574 2009 Hunter et al. licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Given the limited range of effective drug treatments for patients with schizophrenia increasing numbers of patients often termed treatment-resistant are prescribed clozapine. While the induction of neutropenia or agranulocytosis by clozapine is well appreciated other rare potentially fatal adverse reactions may also occur including acute interstitial nephritis as reported in this case. Case presentation A 57-year-old Caucasian woman with treatment-resistant chronic schizophrenia developed acute renal failure following initiation of treatment with clozapine. The adverse reaction occurred after only four doses of the drug had been administered titrated from to 25 mg per day . After clozapine had been withdrawn the patient s renal function returned to normal with no other changes to medication. The patient had been exposed to clozapine about 4 years previously when she had developed a similar reaction. Conclusion .

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