tailieunhanh - 100 Questions in Cardiology - Part 4

Các khái niệm tương đương và ứng dụng của nó để đánh giá 1 của hiệu ứng tan huyết khối. Eur tim J năm 1997; 18: F22-7. 7 Các nhà điều tra sự đồng ý. Viên thức ăn duy nhất tenecteplase so với trước tải alteplase trong nhồi máu cơ tim cấp tính: đồng ý-2 3 thử nghiệm ngẫu nhiên mù đôi. | 54 100 Questions in Cardiology 5 GISSI-2. A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction. Lancet 1990 336 65-71. 6 Hampton JR. The concept of equivalence and its application to the assessment of thrombolytic effects. Eur Heart J 1997 18 F22-7. 7 ASSENT Investigators. Single bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction the ASSENT-2 double blind randomised trial. Lancet 1999 354 716-22. 8 ASSENT-1 Investigators. Safety assessment of a single bolus administration of TNK-tissue plasminogen activator in AMI. Am Heart J 1999 137 786-91. 9 Mukherjee D Ellis SG. Rescue angioplasty for failed thrombolysis. Cleve Clin J Med 2000 67 341-52. 100 Questions in Cardiology 55 26 Is angioplasty better than thrombolysis in myocardial infarction Which patients should receive primary or hot angioplasty for these conditions Vincent S DeGeare and Cindy L Grines In patients with ST elevation myocardial infarction MI there is impressive evidence that primary percutaneous transluminal coronary angioplasty PTCA results in lower morbidity and mortality than does intravenous thrombolysis. This was first demonstrated in the Primary Angioplasty in Myocardial Infarction PAMI trial where primary PTCA resulted in a significant reduction in in-hospital and 6 month composite of death plus non-fatal recurrent myocardial There was also a significant reduction in intracranial bleeding with primary PTCA. The GUSTO IIb angioplasty substudy also showed a significant reduction in the combined end point of death nonfatal reinfarction or disabling stroke at 30 A recent metaanalysis of 10 trials comparing primary PTCA to intravenous thrombolytic therapy showed a 34 reduction in mortality p a 65 reduction in total stroke p and a 91 decrease in haemorrhagic stroke p among patients undergoing primary In addition PTCA has been .