tailieunhanh - báo cáo khoa học: "Mathematical models use varying parameter strategies to represent paralyzed muscle force properties: a sensitivity analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Mathematical models use varying parameter strategies to represent paralyzed muscle force properties: a sensitivity analysis | Journal of NeuroEngineering and Rehabilitation BioMed Central Research Open Access Mathematical models use varying parameter strategies to represent paralyzed muscle force properties a sensitivity analysis Laura A Frey Law and Richard K Shields Address Graduate Program in Physical Therapy and Rehabilitation Science 1-252 Medical Education Bldg. The University of Iowa Iowa City IA USA Email Laura A Frey Law - laura-freylaw@ Richard K Shields - richard-shields@ Corresponding author Published 31 May 2005 Received 22 December 2004 Journal of NeuroEngineering and Rehabilitation 2005 2 12 doi l743- Accepted 3 I May 2005 0003-2-12 This article is available from http content 2 1 12 2005 Law and Shields licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mathematical muscle models may be useful for the determination of appropriate musculoskeletal stresses that will safely maintain the integrity of muscle and bone following spinal cord injury. Several models have been proposed to represent paralyzed muscle but there have not been any systematic comparisons of modelling approaches to better understand the relationships between model parameters and muscle contractile properties. This sensitivity analysis of simulated muscle forces using three currently available mathematical models provides insight into the differences in modelling strategies as well as any direct parameter associations with simulated muscle force properties. Methods Three mathematical muscle models were compared a traditional linear model with 3 parameters and two contemporary nonlinear models each with 6 parameters. Simulated muscle forces were calculated for two stimulation patterns constant frequency