tailieunhanh - Báo cáo y học: " Characterization of a new 5' splice site within the caprine arthritis encephalitis virus genome: evidence for a novel auxiliary protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Characterization of a new 5' splice site within the caprine arthritis encephalitis virus genome: evidence for a novel auxiliary protein. | Retrovirology BioMed Central Research Characterization of a new 5 splice site within the caprine arthritis encephalitis virus genome evidence for a novel auxiliary protein Stephen Valas 1 Morgane Rolland1 2 4 Cécile Perrin1 Gérard Perrin1 and Robert Z Mamoun2 3 Address 1AFSSA-Niort Laboratoire d Etudes et de Recherches Caprines 79012 Niort France 2INSERM U577 Université Victor Segalen Bordeaux 2 146 rue Léo Saignat 33076 Bordeaux France 3CNRS UMR 5235 DIMNP UMII UMI Université Montpellier II CC 107 place E. Bataillon 34095 Montpellier cedex 5 France and 4Department of Microbiology University of Washington Seattle WA 98195-8070 USA Email Stephen Valas - Morgane Rolland - mrolland@ Cécile Perrin - Gérard Perrin - Robert Z Mamoun - Corresponding author Open Access Published 29 February 2008 Received 9 October 2007 Accepted 29 February 2008 Retrovirology 2008 5 22 doi l 742-4690-5-22 This article is available from http content 5 1 22 2008 Valas et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lentiviral genomes encode multiple structural and regulatory proteins. Expression of the full complement of viral proteins is accomplished in part by alternative splicing of the genomic RNA. Caprine arthritis encephalitis virus CAEV and maedi-visna virus MVV are two highly related small-ruminant lentiviruses SRLVs that infect goats and sheep. Their genome seems to be less complex than those of primate lentiviruses since SRLVs encode only three auxiliary proteins namely Tat Rev and Vif in .