tailieunhanh - Báo cáo y học: "Early and transient reverse transcription during primary deltaretroviral infection of sheep"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Early and transient reverse transcription during primary deltaretroviral infection of sheep. | Retrovirology BioMed Central Research Early and transient reverse transcription during primary deltaretroviral infection of sheep Carole Pomier1 Maria T Sanchez Alcaraz2 Christophe Debacq2 Agnes Lanẹon1 Pierre Kerkhofs4 Lucas Willems2 Eric Wattel41 3 and Franck Mortreux 41 Open Access Address 1CNRS FRE3011-Université Claude Bernard Oncovirologie et Biothérapies Centre Léon Bérard Lyon France 2FUSAGx Molecular and cellular biology Gembloux Belgium 3Hôpital Edouard Herriot Service dHématologie Pavillon E Lyon France and Veterinary and Agrochemical Research Centre Department of Virology Uccle Belgium Email Carole Pomier - ptepoms@ Maria T Sanchez Alcaraz - mteresasanchez@ Christophe Debacq - Agnes Lanẹon - lancon@ Pierre Kerkhofs - piker@ Lucas Willems - Eric Wattel - wattel@ Franck Mortreux - mortreux@ Corresponding author tEqual contributors Published I February 2008 Received II July 2007 Accepted 1 February 2008 Retrovirology 2008 5 16 doi 1 742-4690-5-16 This article is available from http content 5 1 16 2008 Pomier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Intraindividual genetic variability plays a central role in deltaretrovirus replication and associated leukemogenesis in animals as in humans. To date the replication of these viruses has only been investigated during the chronic phase of the infection when they mainly spread through the clonal expansion of their host cells vary through a somatic mutation process without evidence for reverse .