tailieunhanh - Báo cáo y học: " Hitting HIV where it hides"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Hitting HIV where it hides. | Retrovirology BioMed Central Commentary Hitting HIV where it hides Andrew I Dayton Open Access Address Laboratory of Molecular Virology Division of Emerging and Transfusion Transmitted Diseases OBRR CBER FDA HFM 315 1401 Rockville Pike Rockville MD 20852-1448 USA Email Andrew I Dayton - Received 30 January 2008 Accepted 1 February 2008 Published 1 February 2008 Retrovirology 2008 5 15 doi 1742-4690-5-15 This article is available from http content 5 1 15 2008 Dayton licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The recent finding that inhibitors of PI3 Akt can sensitize HIV infected macrophages to oxidative stress-induced cell death suggest a potential new therapeutic approach to targeting HIV reservoirs. Although antiretroviral therapy has achieved laudable successes in combating HIV particularly since the advent of protease inhibitors in the mid 1990s fully successful treatment remains plagued by multiple clinically latent viral reservoirs largely impervious to antiretroviral drugs. The microbiology of clinical latency is controversial and may involve elements of viral quiescence expression of no - or a limited subset of - viral genes as well as low level viral replication in protected cell types or anatomical compartments 1 . Viral persistence has been reported in brain cells including perivascular macrophages parenchymal microglial cells and astrocytes NK cells renal tubular cells mononuclear cells from semen follicular dendritic cells cells of the monocyte macrophage lineage recently infected monocytes and tissue macrophages and resting CD4 T cells with the latter two being the best known reservoirs 2-5 . Attempts at attacking the resting CD4 T cell HIV