tailieunhanh - Báo cáo y học: "Host factors influencing susceptibility to HIV infection and AIDS progression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Host factors influencing susceptibility to HIV infection and AIDS progression. | Retrovirology BioMed Central Review Open Access Host factors influencing susceptibility to HIV infection and AIDS progression Juan Lama 1 2 and Vicente Planelles3 Address 1La Jolla Institute for Molecular Medicine 4570 Executive Drive Suite 100 San Diego California 92121 USA 2RetroVirox Inc. 4570 Executive Drive Suite 100 San Diego California 92121 USA and 3Department of Pathology University of Utah School of Medicine 15 North Medical Drive East 2100 - Room 2520 Salt Lake City Utah 84112 UsA Email Juan Lama - jlama@ Vicente Planelles - Corresponding author Published 25 July 2007 Received 16 May 2007 Retrovirology 2007 4 52 doi 1742-4690-4-52 Accepted 25 July 2007 This article is available from http content 4 1 52 2007 Lama and Planelles licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Transmission of HIV first results in an acute infection followed by an apparently asymptomatic period that averages ten years. In the absence of antiretroviral treatment most patients progress into a generalized immune dysfunction that culminates in death. The length of the asymptomatic period varies and in rare cases infected individuals never progress to AIDS. Other individuals whose behavioral traits put them at high-risk of HIV transmission surprisingly appear resistant and never succumb to infection. These unique cases highlight the fact that susceptibility to HIV infection and progression to disease are complex traits modulated by environmental and genetic factors. Recent evidence has indicated that natural variations in host genes can influence the outcome of HIV infection and its transmission. In this review we summarize the available literature on the