tailieunhanh - Báo cáo y học: " Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation. | Retrovirology BioMed Central Open Access Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1 Implications for transformation Murali VP Nadella1 2 Sherry T Shu1 2 Wessel P Dirksen1 2 Nanda K Thudi1 Kiran S Nadella3 Soledad A Fernandez2 4 Michael D Lairmore1 2 Patrick L Green1 2 and Thomas J Rosol 1 2 Address Department of Veterinary Biosciences The Ohio State University Columbus OH USA 2Center for Retrovirus Research The Ohio State University Columbus OH USA 3Human Cancer Genetics The Ohio State University Columbus OH USA and 4Center for Biostatistics The Ohio State University Columbus OH USA Email Sherry T Shu - Wessel P Nanda K Thudi - thudi. 1@ Kiran S Nadella - Soledad A Fernandez - Michael D Lairmore - Patrick L Green - Thomas J Rosol - Corresponding author Published 9 June 2008 Received 10 March 2008 Retrovirology 2008 5 46 doi 1742-4690-5-46 Accepted 9 June 2008 This article is available from http content 5 1 46 2008 Nadella et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Adult T-cell leukemia lymphoma ATLL is initiated by infection with human T-lymphotropic virus type-1 HTLV-1 however additional host factors are also required for T-cell transformation and development of ATLL. The HTLV-1 Tax protein plays an important role in the transformation of T-cells although the exact mechanisms remain unclear. Parathyroid hormone-related protein PTHrP plays an important role in .

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