tailieunhanh - Báo cáo y học: " Human Polycomb group EED protein negatively affects HIV-1 assembly and release"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Human Polycomb group EED protein negatively affects HIV-1 assembly and release. | Retrovirology BioMed Central Open Access Human Polycomb group EED protein negatively affects HIV-I assembly and release Dina Rakotobe1 Jean-Claude Tardy1 2 Patrice André2 Saw See Hong1 Jean-Luc Darlix3 and Pierre Boulanger 1 4 Address 1Laboratoire de Virologie Pathologie Humaine Université Lyon I CNRS FRE-3011 Faculté de Médecine Laennec 7 rue Guillaume Paradin 69372 Lyon Cedex 08 France 2Laboratoire de Virologie Médicale-Nord Hôpital de la Croix-Rousse Hospices Civils de Lyon 103 Grand Rue de la Croix-Rousse 69317 Lyon Cedex 04 France 3LaboRétro Unité de Virologie Humaine INSERM U-758 IFR128 BioSciences Lyon-Gerland Ecole Normale Supérieure 46 allée d Italie 69364 Lyon Cedex 07 France and 4Laboratoire de Virologie Médicale Hospices Civils de Lyon CBPE 59 Boulevard Pinel 69677 Bron Cedex France Email Dina Rakotobe - dinaraktb@ Jean-Claude Tardy - Patrice André - Saw See Hong - Jean-Luc Darlix - jldarlix@ Pierre Boulanger - Corresponding author Published 4 June 2007 Received 22 January 2007 Retrovirology 2007 4 37 doi 1742-4690-4-37 Accepted 4 June 2007 This article is available from http content 4 1 37 2007 Rakotobe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human EED protein a member of the superfamily of Polycomb group PcG proteins with WD-40 repeats has been found to interact with three HIV-1 components namely the structural Gag matrix protein MA the integrase enzyme IN and the Nef protein. The aim of the present study was to analyze the possible biological role of EED in HIV-1 replication using the HIV-1-based .

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