tailieunhanh - Báo cáo y học: "HIV-1 drug-resistance and drug-dependence"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 drug-resistance and drug-dependence. | Retrovirology BioMed Central Review HIV-1 drug-resistance and drug-dependence Chris Baldwin and Ben Berkhout Open Access Address Laboratory of Experimental Virology Department of Medical Microbiology Center for Infection and Immunity Amsterdam CINIMA Academic Medical Center of the University of Amsterdam the Netherlands Email Chris Baldwin - baldwin_ce@ Ben Berkhout - Corresponding author Published 25 October 2007 Received 20 June 2007 Accepted 25 October 2007 Retrovirology 2007 4 78 doi 1742-4690-4-78 This article is available from http contentM 1 78 2007 Baldwin and Berkhout licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In this review we will describe several recent HIV-I studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second a compensatory mutation that repairs the protein function but in the presence of the drug which becomes an intrinsic part of the mechanism. The clinical relevance of drugdependent HIV-1 variants is also discussed. Introduction to the HIV-1 drug-dependence phenomenon We previously described the emergence of a drug-dependent HIV-1 variant in a patient on T20 enfuvirtide therapy 1 . This variant first acquired a resistance mutation in the T20-binding site of the envelope Env protein that provided resistance to the inhibitor but at a fitness cost. The virus then evolved further to repair this fitness defect by introducing a second-site compensatory mutation in the Env protein. This evolution event took place in the presence of the .

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