tailieunhanh - Báo cáo y học: "Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo. | Retrovirology BioMed Central Open Access Human prostate supports more efficient replication of HIV-I R5 than X4 strains ex vivo Anna Le Tortorec1 2 Anne-Pascale Satie1 2 Hélène Denis1 2 Nathalie Rioux-Leclercq4 5 Laurence Havard3 Annick Ruffault3 Bernard légou1 2 and Nathalie Dejucq-Rainsford 1 2 Address 1Inserm U625 Rennes France 2Univ Rennes I Campus de Beaulieu IFR-140 GERHM Rennes F-35042 France 3Unité de rétrovirologie CHU Pontchaillou Rennes France 4Service d anatomie et cytologie pathologiques CHU Pontchaillou Rennes France and 5CNRS UMR6061 IFR140 Faculté de Médecine Université de Rennes1 France Email Anna Le Tortorec - Anne-Pascale Satie - Hélène Denis - helenebruneau@ Nathalie Rioux-Leclercq - Laurence Havard - Annick Ruffault - Bernard Jégou - .fr Nathalie Dejucq- Rainsford - Corresponding author Published 31 December 2008 Received 20 November 2008 Accepted 31 December 2008 Retrovirology 2008 5 119 doi l742-4690-5-119 This article is available from http content 5 1 1 19 2008 Le Tortorec et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In order to determine whether human prostate can be productively infected by HIV-1 strains with different tropism and thus represent a potential source of HIV in semen an organotypic culture of prostate from men undergoing prostatic adenomectomy for benign prostate hypertrophy BPH was developed. The presence of potential HIV target cells in prostate tissues was investigated using .