tailieunhanh - Báo cáo y học: " Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. | Retrovirology BioMed Central Research Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication Jasmine K Ahluwalia1 Sohrab Zafar Khan2 Kartik Soni1 Pratima Rawat2 Ankit Gupta1 Manoj Hariharan1 Vinod Scaria1 Mukesh Lalwani1 Beena Pillai1 Debashis Mitra2 and Samir K Brahmachari 1 Address institute of Genomics and Integrative Biology IGIB CSIR Mall Road Delhi-110007 India and 2National Centre for Cell Science NCCS University of Pune campus Ganeshkhind Pune-411007 Maharashtra India Email Jasmine K Ahluwalia - Sohrab Zafar Khan - sohrabzafar@ Kartik Soni - Pratima Rawat - rawatpratima2003@ Ankit Gupta - ManojHariharan - manoj@ Vinod Scaria - vinods@ Mukesh Lalwani - Beena Pillai - beenapillai@ Debashis Mitra - dmitra@ Samir K Brahmachari - skb@ Corresponding author Open Access Published 23 December 2008 Received 25 June 2008 Accepted 23 December 2008 Retrovirology 2008 5 117 doi 1742-4690-5-117 This article is available from http content 5 1 1 17 2008 Ahluwalia et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cellular miRNAs play an important role in the regulation of gene expression in eukaryotes. Recently miRNAs have also been shown to be able to target and inhibit viral gene expression. Computational predictions revealed earlier that the HIV-1 genome includes regions that may be potentially targeted by human miRNAs. Here we report the functionality of predicted miR-29a target site