tailieunhanh - Báo cáo y học: "beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL. | Retrovirology BioMed Central Open Access Short report beta-estradiol attenuates the anti-HIV-l efficacy of Stavudine D4T in primary PBL Mingjie Zhang1 Qingsheng Huang1 Yong Huang1 Owen Wood1 Weishi Yuan1 Caren Chancey1 Sylvester Daniel1 Maria Rios1 Indira Hewlett1 Kathleen A Clouse2 and Andrew I Dayton 1 Address 1Center for Biologics Evaluation and Research Food and Drug Administration 1401 Rockville Pike Rockville MD 20852 USA and 2Center for Drug Eveluation and Research Food and Drug Administration 5600 Fishers Lane Rockville MD 20857 USA Email Mingjie Zhang - Qingsheng Huang - Yong Huang - Owen Wood - Weishi Yuan - Caren Chancey - Sylvester Daniel - Maria Rios - Indira Hewlett - Kathleen A Clouse - Andrew I Dayton - Corresponding author Published 22 September 2008 Received 20 December 2007 Accepted 22 September 2008 Retrovirology 2008 5 82 doi l 742-4690-5-82 This article is available from http content 5 1 82 2008 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV AIDS progression. Here we ask whether the sex steroid hormone P-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug Stavudine D4T . Results Human PBL