tailieunhanh - Báo cáo y học: " Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity. | Retrovirology BioMed Central Open Access Induction of galectin-l expression by HTLV-I Tax and its impact on HTLV-I infectivity Sonia Gauthier1 Isabelle Pelletier1 Michel Ouellet1 Amandine Vargas2 Michel J Tremblay1 Sachiko Sato1 and Benoit Barbeau 2 Address Research Center in Infectious Diseases CHUL Research Center 2705 boul. Laurier Ste-Foy Québec G1V 4G2 Canada and 2Université du Québec à Montréal Département des sciences biologiques 2080 St-Urbain Montréal Québec H2X 3X8 Canada Email Sonia Gauthier - Isabelle Pelletier - Michel Ouellet - Amandine Vargas - Michel J Tremblay - Sachiko Sato - Benoit Barbeau - Corresponding author Published 25 November 2008 Received 16 June 2008 Accepted 25 November 2008 Retrovirology 2008 5 105 doi 1742-4690-5-105 This article is available from http content 5 1 105 2008 Gauthier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cell-free Human T-cell Leukemia Virus type I HTLV-I virions are poorly infectious and cell-to-cell contact is often required to achieve infection. Other factors might thus importantly contribute in increasing infection by HTLV-I. Galectin-1 is a galactoside-binding lectin which is secreted by activated T lymphocytes. Several functions have been attributed to this protein including its capacity to increase cell-to-cell adhesion. Based on previous studies we postulated that this protein could also accentuate HTLV-I infection. Results Herein we demonstrate that galectin-1 expression and release are higher .