tailieunhanh - Báo cáo y học: " Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. | Retrovirology BioMed Central Open Access Review Multi-stage Friend murine erythroleukemia molecular insights into oncogenic cooperation Fran oise Moreau-Gachelin1 2 Address 1Inserm U830 26 rue d Ulm 75248 Paris cedex 05 France and 2Institut Curie 26 rue d Ulm 75248 Paris cedex 05 France Email Fran oise Moreau-Gachelin - framoreau@ Published 4 November 2008 Received 2 October 2008 Retrovirology 2008 5 99 doi 1742-4690-5-99 Accepted 4 November 2008 This article is available from http content 5 1 99 2008 Moreau-Gachelin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The Friend virus SFFV Spleen Focus Forming Virus provokes an acute erythroblastosis in susceptible strains of mice that progresses to overt erythroleukemia by a multi-step process. For virologists the Friend virus-induced disease has provided deep insights into the host mechanisms influencing susceptibility to retroviral infection and viremia. These insights have contributed to the understanding of HIV and other human retroviral infections. For cell biologists and oncologists this leukemia has been a powerful experimental model to identify critical oncogenes involved in a multistage process to understand the contribution of host genes to cancer development and to investigate the mechanisms leading to cell growth autonomy. This model also provided an example of oncogenic reversion since Friend tumor cells can reinitiate their erythroid differentiation program when exposed in vitro to some chemical inducers. This review highlights recent findings demonstrating that the leukemic progression depends on the cooperation of at least two oncogenic events one interfering with differentiation and one conferring a proliferative

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