tailieunhanh - Báo cáo y học: " The HTLV-1 Tax interactome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The HTLV-1 Tax interactome. | Retrovirology BioMed Central Open Access Review The HTLV-1 Tax interactome Mathieu Boxus Jean-Claude Twizere Sébastien Legros Jean-Franẹois Dewulf Richard Kettmann and Luc Willems Address University Academia Wallonie-Europe Molecular and Cellular Biology at FUSAGx Gembloux Belgium Email Mathieu Boxus - Jean-Claude Twizere - Sébastien Legros - Jean-Francois Dewulf-dewulfjeanfrancois@ Richard Kettmann - Luc Willems - Corresponding author Published 14 August 2008 Received 19 June 2008 Accepted 14 August 2008 Retrovirology 2008 5 76 doi 186 1742-4690-5-76 This article is available from http content 5 1 76 2008 Boxus et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation proliferation and ultimately transformation. To carry out these functions Tax1 interacts with and modulates activity of a number of cellular proteins. In this review we summarize the present knowledge of the Taxl interactome and propose a rationale for the broad range of cellular proteins identified so far. 1 Introduction Human T-lymphotropic viruses HTLV-1 to -4 belong to the Deltaretrovirus genera of the Orthoretrovirinae subfamily. HTLV-1 was the first discovered human retrovirus in the early eighties 1 . HTLV-2 was described two years later 2 whereas HTLV-3 and -4 subtypes were isolated only recently 3 4 . HTLV-1 is the etiological agent of an aggressive leukemia called adult T-cell .