tailieunhanh - Báo cáo y học: " Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements. | Retrovirology BioMed Central Open Access Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle ex vivo effects and in vivo traces on the murine IAPE and human HERV-K elements Cécile Esnaultf1 Stéphane Prietd1 2 David Ribett1 3 Odile Heidmannt1 and Thierry Heidmann 1 Address 1Unité des Rétrovirus Endogènes et Eléments Rétroĩdes des Eucaryotes Supérieurs CNRS UMR 8122 Institut Gustave Roussy 39 rue Camille Desmoulins F-94805 Villejuif and Université Paris-Sud Orsay F-91405 France 2Architecture et Fonction des Macromolécules Biologiques CNRS UMR 6098 ESIL case 925 F-13288 Marseille Cedex 9 France and 3Unité des interactions Bactéries-Cellules INSERM U604 INRA USC2020 Institut Pasteur 25 rue du Dr Roux F-75024 Paris Cedex 15 France Email Cécile Esnault - cesnault@ Stéphane Priet - David Ribet - dribet@ Odile Heidmann - oheidmann@ Thierry Heidmann - heidmann@ Corresponding author tEqual contributors Published 14 August 2008 Received 24 June 2008 Retrovirology 2008 5 75 doi 1742-4690-5-75 Accepted I4 August 2008 This article is available from http content 5 1 75 2008 Esnault et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background APOBEC3 cytosine deaminases have been demonstrated to restrict infectivity of a series of retroviruses with different efficiencies depending on the retrovirus. In addition APOBEC3 proteins can severely restrict the intracellular transposition of a series of retroelements with a strictly intracellular life cycle including the murine IAP and MusD LTR-retrotransposons. Results Here we