tailieunhanh - Báo cáo y học: "HLA-C increases HIV-1 infectivity and is associated with gp120"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "HLA-C increases HIV-1 infectivity and is associated with gp120. | Retrovirology BioMed Central Open Access HLA-C increases HIV-1 infectivity and is associated with gp120 Andrea Matucci1 Paola Rossolillo1 Miriam Baroni2 Antonio G Siccardi2 Alberto Beretta3 and Donato Zipeto 1 Address laboratory of Molecular Biology Department of Mother and Child Biology and Genetics Section of Biology and Genetics University of Verona Strada le Grazie 8 37134 Verona Italy 2University of Milan and DIBIT-San Raffaele Scientific Institute Via Olgettina 58 20132 Milan Italy and 3Infectious Diseases Department IRCCS Ospedale San Raffaele Via Stamira d Ancona 20 20127 Milan Italy Email Andrea Matucci - Paola Rossolillo - Miriam Baroni - Antonio G Siccardi - Alberto Beretta - Donato Zipeto - Corresponding author Published I August 2008 Received 13 June 2008 Retrovirology 2008 5 68 doi 1742-4690-5-68 Accepted 1 August 2008 This article is available from http content 5 1 68 2008 Matucci et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background A recently identified genetic polymorphism located in the 5 region of the HLA-C gene is associated with individual variations in HIV-1 viral load and with differences in HLA-C expression levels. HLA-C has the potential to restrict HIV-1 by presenting epitopes to cytotoxic T cells but it is also a potent inhibitor of NK cells. In addition HLA-C molecules incorporated within the HIV-1 envelope have been shown to bind to the envelope glycoprotein gp 120 and enhance viral infectivity. We .

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