tailieunhanh - Báo cáo y học: " Regulation of primate lentiviral RNA dimerization by structural entrapment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Regulation of primate lentiviral RNA dimerization by structural entrapment. | Retrovirology BioMed Central Research Regulation of primate lentiviral RNA dimerization by structural entrapment Tayyba T Baig Christy L Strong J Stephen Lodmell and Jean-Marc Lanchy Address Division of Biological Sciences The University of Montana Missoula MT 59812 USA Email TayybaT Baig - Christy L Strong - J Stephen Lodmell - Jean-Marc Lanchy - Corresponding author Open Access Published 17 July 2008 Received 22 March 2008 Retrovirology 2008 5 65 doi 1742-4690-5-65 Accepted I7 July 2008 This article is available from http content 5 1 65 2008 Baig et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Genomic RNA dimerization is an important process in the formation of an infectious lentiviral particle. One of the signals involved is the stem-loop 1 SL1 element located in the leader region of lentiviral genomic RNAs which also plays a role in encapsidation and reverse transcription. Recent studies revealed that HIV types 1 and 2 leader RNAs adopt different conformations that influence the presentation of RNA signals such as SL1. To determine whether common mechanisms of SL1 regulation exist among divergent lentiviral leader RNAs here we compare the dimerization properties of SIVmac239 HIV-1 and HIV-2 leader RNA fragments using homologous constructs and experimental conditions. Prior studies from several groups have employed a variety of constructs and experimental conditions. Results Although some idiosyncratic differences in the dimerization details were observed we find unifying

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