tailieunhanh - Báo cáo y học: " Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities. | Retrovirology BioMed Central Research Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities Laetitia Carthagena1 2 Mélanie C Parise1 2 Mathieu Ringeard1 2 Mounira K Chelbi-Alix3 Uriel Hazan1 2 4 and Sébastien Nisole 1 2 4 Open Access Address 1Institut Cochin Université Paris Descartes CNRS UMR 8104 Département des Maladies Infectieuses 22 rue Méchain 75014 Paris France 2INSERM U567 Paris France 3CNRS FRE 2937 Institut André Lwoff Villejuif France and 4Université Paris Diderot-Paris 7 UFR de Biochimie Paris France Email Laetitia Mélanie C Parise - Mathieu Ringeard - Mounira K Chelbi-Alix - mchelbi@ Uriel Hazan - Sébastien Nisole - Corresponding author Published 9 July 2008 Received 29 April 2008 Retrovirology 2008 5 59 doi 1742-4690-5-59 Accepted 9 July 2008 This article is available from http content 5 1 59 2008 Carthagena et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background TRIM5a is a restriction factor that interferes with retroviral infections in a speciesspecific manner in primate cells. Although TRIM5a is constitutively expressed its expression has been shown to be up-regulated by type I interferon IFN . Among primates a particular case exists in owl monkey cells which express a fusion protein between TRIM5 and cyclophilin A TRIMCyp specifically interfering with HIV-1 infection. No studies have been conducted so far concerning the possible induction of TRIMCyp by IFN. We investigated the .