tailieunhanh - Báo cáo y học: " VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability. | BioMed Central Retrovirology Research VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability Sonia Brun1 2 3 Maxime Solignat1 2 3 Bernard Gay1 2 3 Eric Bernard1 2 3 Laurent Chaloin1 2 3 David Fenard1 2 3 4 Christian Devaux1 2 3 Nathalie Chazal1 2 3 and Laurence Briant 1 2 3 Address 1Université Montpellier 1 Centre d etudes d agents Pathogènes et Biotechnologies pour la Santé CPBS France 2CNRS UMR 5236 CPBS F-34965 Montpellier France 3Université Montpellier 2 CPBS F-34095 Montpellier France and 4GENETHON 1bis rue de l Internationale - BP60 91002 EVRY cedex France Email Sonia Brun - Maxime Solignat - Bernard Gay - Eric Bernard - Laurent Chaloin - David Fenard-dfenard@ Christian Nathalie Chazal - Laurence Briant - Corresponding author Open Access Published 7 July 2008 Received 11 February 2008 Retrovirology 2008 5 57 doi 1742-4690-5-57 Accepted 7 July 2008 This article is available from http content 5 1 57 2008 Brun et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The machinery of early HIV-1 replication still remains to be elucidated. Recently the viral core was reported to persist in the infected cell cytoplasm as an assembled particle giving rise to the reverse transcription complex responsible for the synthesis of proviral DNA and its transport to the nucleus. Numerous studies have demonstrated that reverse transcription of the HIV-1 genome into proviral DNA is tightly dependent upon .