tailieunhanh - PLANTS THAT FIGHT CANCER - PART 6

Các hoạt động antiproliferative tanshinones chống lại tế bào khối u của con người, có nghĩa là, A-549 (phổi), SK-OV-3 (buồng trứng), SK-MEL-2 (khối u ác tính), XF-498 (hệ thống trung tâm thần kinh) và HCT-15 (đại tràng), được đánh giá bằng phương pháp sulfrhodamine-B | 148 Spiridon E. Kintzios et al. which may lead to possible mutagenesis and or carcinogenesis and form the basis of spontaneous cancer incidence. Free radicals play an important role in preventing deleterious alterations in cellular DNA and genotoxic effects caused by ionizing radiation in mammalian tissues. Many drugs and chemicals for example sulfhydryl compounds are known to increase the survival rate in animals. Based on animal models studies 5. milliorrhiza and its extracts were shown to have a potential to prevent X-radiation-induced pulmonary injuries and high dosage gamma-irradiation-induced platelet aggregation lesions. The antiproliferative activity of tanshinones against five human tumor cells that is A-549 lung SK-OV-3 ovary SK-MEL-2 melanoma XF-498 central nerve system and HCT-15 colon was evaluated by sulfrhodamine-B method. Eighteen isolated tanshinones exhibited significant but presumably nonspecific cytotoxicity against all tested tumor cells which might be attributed to common naphtoquinone skeleton rather than to substituents attached to it. Methylenetanshiquinone and tan-shindiol C exhibited most powerful cytotoxic effects against tested tumor cells with IC50 ranging from 1 in A-549 cells to pg ml 1 in SK-MEL-2 cells and IC50 from pgml 1 in SK-MEL-2 cells to 1 in SK-OV-3 cancer cell lines respectively. Related species From 5. przewalskii Maxim. var. mandarinorum Stib. a strong bacteriostatic compound przewaquinone A was isolated Yang et al. 1981 1984 . Przewaquinone A was reported to possess potential for inhibiting Lewis lung carcinoma and melanoma B-16. References Darias V. Bravo L. Rabanal R. Sữnchez-Mateo . and Martvn-Herrera . 1990 Cytostatic and antibacterial activity of some compounds isolated from several lamiaceae species from the Canary Islands. Planta Med. 56 70 2. Du H. Quian Z. and Wang Z. 1990 Prevention of radiation injury of the lungs by Salvia miltiorrbiza in mice. Chinese J. Mod. Develop. Trad. Med.