tailieunhanh - Diagnosis and Treatment of Wilson Disease: An Update

Ethnic-religion hostilities which started in February 2004 in shimkar and Kelwa in Plateau state, with the conflict spreading to neigbouring communities of Zomo, Doka and Lopidi, Laraba and Unguwar Adamu. Many people were wounded and houses burnt. On 13 May 2004, a total of 735 internally-displaced families were sheltered in school compounds, markets and mosques in Lafia town of Nassarawa state. This figure includes 1,543 displaced children (The Federation’s Mission, 2004). Malaria, diarrhea, measles, pneumonia, tuberculoses, meningitis and enteric parasitic infections are the most common infection diseases in many refuges or idps camps in Africa. Factors that. | AASLD PRACTICE GUIDELINES Diagnosis and Treatment of Wilson Disease An Update Eve A. Roberts1 and Michael L. Schilsky2 This guideline has been approved by the American Association for the Study of Liver Diseases AASLD and represents the position of the association. Preamble These recommendations provide a data-supported approach to the diagnosis and treatment of patients with Wilson disease. They are based on the following 1 formal review and analysis of the recently-published world literature on the topic including Medline search 2 American College of Physicians Manual for Assessing Health Practices and Designing Practice Guidelines1 3 guideline policies including the AASLD Policy on the Development and Use of Practice Guidelines and the American Gastroenterological Association Policy Statement on Guidelines2 4 the experience of the authors in the specified topic. A significant problem with the literature on Wilson disease is that patients are sufficiently rare to preclude large cohort studies or randomized controlled trials moreover most treatment modalities were developed at a time when conventions for drug assessment were less stringent than at present. Intended for use by physicians these recommendations suggest preferred approaches to the diagnostic therapeutic and preventive aspects of care. They are intended to be flexible in contrast to standards of care which are inflexible policies to be followed in every case. Specific recommendations are based on relevant published information. To characterize more fully the quality of evidence supporting recommendations the Practice Guidelines Committee of the AASLD requires a class reflecting ben- Abbreviations AASLD American Association for the Study of Liver Diseases BAL British anti-Lewisite MR magnetic resonance TM tetrathiomolybdate WD Wilson disease. From the1Division ofGastroenterology HepatologyandNutrition TheHospital for Sick Children and Departments of Paediatrics Medicine and Pharmacology University of .